The Case for High-Dose Dexamethasone Suppression Testing Preoperatively in Aldosterone-Producing Adenoma to Exclude Cosecretion of Cortisol

The case for high-dose dexamethasone suppression testing preoperatively in aldosterone-producing adenoma to exclude cosecretion of cortisol.

nature publishing group COMMENTARY T he case report by Rossi and coworkers in this issue of the journal 1 contains important messages, and in discussion raises interesting issues. First, adrenal tumors can cosecrete more than one hormone, in this case cortisol as well as aldosterone in a patient with Conn's syndrome. Second, when unilateral adrenalectomy is performed for a tumor secreting corti...

the test for adverse selection in life insurance market: the case of mellat insurance company

انتخاب نامساعد یکی از مشکلات اساسی در صنعت بیمه است. که ابتدا در سال 1960، توسط روتشیلد واستیگلیتز مورد بحث ومطالعه قرار گرفت ازآن موقع تاکنون بسیاری از پژوهشگران مدل های مختلفی را برای تجزیه و تحلیل تقاضا برای صنعت بیمه عمر که تماما ناشی از عدم قطعیت در این صنعت میباشد انجام داده اند .وهدف از آن پیدا کردن شرایطی است که تحت آن شرایط انتخاب یا کنار گذاشتن یک بیمه گزار به نفع و یا زیان شرکت بیمه ...

Repeating adrenal vein sampling when neither aldosterone/cortisol ratio exceeds peripheral yields a high incidence of aldosterone-producing adenoma.

OBJECTIVES In primary aldosteronism, adrenal vein sampling (AVS) suggests unilateral aldosterone-producing adenoma (APA) when the aldosterone/cortisol (A/F) ratio is less than or equal to peripheral on one side and at least two times peripheral on the other. When A/F ratios are lower bilaterally than peripheral despite adequate samples (adrenal venous cortisol ≥3 times peripheral), we recommend...

[Laparoscopic partial adrenalectomy for aldosterone-producing adenoma].

Hypomethylation of CYP11B2 in Aldosterone-Producing Adenoma.

The purpose of this study was to evaluate the DNA methylation levels of steroidogenic enzyme genes in aldosterone-producing adenoma (APA) and the effects of gene mutations in APA on the DNA methylation levels. DNA methylation array analysis was conducted using nonfunctioning adrenocortical adenoma (n=12) and APA (n=35) samples, including some with a KCNJ5 mutation (n=21), an ATP1A1 mutation (n=...